meropenem side effects

(1.3%), shock (1.2%), and pruritus (1.2%). This is not a complete list of side effects and others may occur. chills. fainting. Meropenem and vaborbactam injection may cause side effects. Pneumonia may be contagious for 2-14 days. MERREM IV was studied in 200 neonates and infants less than 3 months of age. A second infection may happen. Skin And Subcutaneous Disorders: Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS), erythema multiforme and acute generalized exanthematous pustulosis. What is meningitis and what causes it? Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. Case reports in the literature have shown that co-administration of carbapenems, including meropenem, to patients receiving valproic acid or divalproex sodium results in a reduction in valproic acid concentrations. Systemic adverse events that were reported with MERREM IV occurring in greater than 1.0% of the patients were diarrhea (4.8%), nausea/vomiting (3.6%), headache (2.3%), rash (1.9%), sepsis (1.6%), constipation (1.4%), apnea (1.3%), shock (1.2%), and pruritus (1.2%). Get our free fact sheet. Constipation 3. Meropenem may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and requires immediate medical attention. The types of systemic and local adverse events seen in these patients are similar to the adults, with the most common adverse events reported as possibly, probably, or definitely related to Merrem IV and their rates of occurrence as follows: Pediatric Patients with Bacterial Meningitis. The most common adverse events occurring in greater than 5% of the patients were: Adverse events with an incidence of greater than 1%, and not listed above, include: For patients with varying degrees of renal impairment, the incidence of heart hematocrit, decreased white blood cell (WBC), shortened prothrombin time and shortened partial thromboplastin time, Below is a summary of known side effects for MERREM IV. Shortness of breath. Symptoms and signs include cough, fever, shortness of breath, and chills. Common side effects of meropenem include diarrhea, nausea and vomiting, and headache. In the Merrem IV treated group, 12/15 patients with seizures had late onset seizures (defined as occurring on day 3 or later) versus 7/20 in the comparator arm. During clinical investigations, 2904 immunocompetent adult patients were treated for non-CNS infections with Merrem IV (500 mg or 1 gram every 8 hours). Adequate and well-controlled studies of this drug in pregnant women are lacking, and this drug should be used during pregnancy only if clearly needed. Laboratory changes seen in the pediatric studies, including the meningitis studies, were similar to those reported in the adult studies. Risk of Breakthrough Seizures Due to Drug Interaction with Valproic Acid. Additional systemic adverse events that were reported with MERREM IV and occurring in less than or equal to 1.0% but A severe and sometimes deadly reaction has happened. Although the mechanism of this interaction is unknown, data from in vitro Merrem IV (meropenem injection) side effects list for healthcare professionals. Merrem IV was studied in 321 pediatric patients (3 months to less than 17 years of age) with meningitis at a dosage of 40 mg/kg every 8 hours. Although not all of these side effects may occur, if they do occur they may need medical attention. In case of a severe side effect or reaction, call the doctor, nurse or pharmacist at 595-3300. E coli O157:H7 commonly is due to eating raw or undercooked hamburger or raw milk or dairy products. It’s good at treating severe and complicated bacterial infections. Should I Get the Pneumonia Vaccine Every Year? Serious adverse effects are rare. These may be encountered; Pain at the site of injection. What are the possible side effects of meropenem? Read the entire FDA prescribing information for Merrem IV (Meropenem). Background: Drug-induced immune thrombocytopenia (DITP) is a serious, life-threatening clinical syndrome, the diagnosis of which is consistently difficult. 1. Blood And Lymphatic System Disorders: agranulocytosis, neutropenia, and leukopenia; a positive direct or indirect Coombs test, and hemolytic anemia. dehydrogenase (LDH), and bilirubin, Hematologic: increased platelets, increased eosinophils, decreased platelets, decreased hemoglobin, decreased In the MERREM IV treated group, 12/15 patients with seizures had late onset seizures (defined as occurring on day 3 or later) versus 7/20 in the comparator arm. Antibiotics treat E. coli infection. Merrem IV (meropenem injection) is a carbapenem antibiotic used to treat a variety of bacteria. intestinal obstruction, Hemic/Lymphatic: anemia, hypochromic anemia, hypervolemia, Metabolic/Nutritional: peripheral edema, hypoxia, Nervous System: insomnia, agitation, delirium, confusion, dizziness, seizure, nervousness, paresthesia, hallucinations, It kills bacteria that are resistant to other antibiotics. Serious side effects of Merrem IV include. By continuing to browse this site you are agreeing to our use of cookies. … The most common adverse events occurring in greater than 5% of the patients were: headache (7.8%), nausea (7.8%), constipation (7.0%), diarrhea (7.0%), anemia (5.5%), and pain (5.1%). Transiently elevated liver enzymes were the most common side-effect. It should be used during pregnancy only if clearly needed. Examples of strains include: EHEC (enterohemorrhagic E. coli), ETEC (enterotoxigenic E. coli), EPEC (enteropathogenic E. coli), EIEC (enteroinvasive E. coli), EAEC (enteroadherent E. coli), and EAggEC (enteroaggregative E. coli). Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. Amropenem (500 mg) 500mg - 1 Vial Injection (Meropenem) drug information. Merrem IV (meropenem injection) is a carbapenem antibiotic used to treat a variety of bacteria, including E. coli, H. influenzae, K. pneumoniae, N. meningitidis, P. aeruginosa, and others. Deaths in 5 patients were assessed as possibly related to meropenem; 36 (1.2%) patients had meropenem discontinued because of adverse events. Most pneumonias are caused by bacteria and viruses, but some pneumonias are caused by inhaling toxic chemicals that damage lung tissue. Does Merrem IV (meropenem injection) cause side effects? Co-administration of meropenem IV with valproic acid or divalproex sodium reduces serum concentrations of valproic acid potentially increasing risk of breakthrough seizures. diarrhea (4.8%), nausea/vomiting (3.6%), headache (2.3%), rash (1.9%), sepsis (1.6%), constipation (1.4%), apnea Side Effects Swelling, redness, pain, or soreness at the injection site may occur. mL/min). Find its price or cost, dose, when to use, how to use, side effects, adverse effects, substitutes. Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple … failure, kidney failure, seizure and shock reported with Merrem IV, increased in home There are several subtypes of the E. coli Serious side effects include Clostridium difficile infection, seizures, and allergic reactions including anaphylaxis. The types of systemic and local adverse events seen in these patients are similar to the adults, with the most common adverse events reported as possibly, probably, or definitely related to MERREM IV and their rates of occurrence as follows: Pediatric Patients with Bacterial Meningitis. The study was open-label, uncontrolled, 98% of the infants received concomitant medications, and the majority of adverse events were reported in neonates less than 32 weeks gestational age and critically ill at baseline, making it difficult to assess the relationship of the adverse events to Those who are allergic to other β-lactam antibiotics are more likely to be allergic to meropenem as well. severe diarrhea (watery or bloody stools) that may occur with or without fever and stomach cramps (may occur up to 2 months or more after your treatment) hives. (Meropenem) side effects drug center, Pharmacy Editor: Melissa Conrad Stöppler, MD. Symptoms may vary depending on the strain the individual contracts. Pneumonia can be deadly. The adverse reactions seen in these patients that were reported and their rates of occurrence are as follows: Adverse Laboratory Changes in Pediatric Patients. Probenecid (Benemid) may increase levels of meropenem by reducing its elimination through the kidneys. Laboratory changes seen in the pediatric studies, including the meningitis studies, were similar to those reported in the adult studies. Meningitis, inflammation of the meninges, symptoms and signs include neck stiffness, headache, and fever. CLINICAL PHARMACOLOGY]. greater than 0.1% of the patients are listed below within each body system in order of decreasing frequency: Bleeding events were seen as follows: gastrointestinal hemorrhage (0.5%), melena (0.3%), epistaxis (0.2%), Use in pregnancy appears to be safe. There are five types of meningitis: viral, bacterial, fungal, parasitic, and noninfectious. dehydrogenase (LDH), and bilirubin, Hematologic: increased platelets, increased eosinophils, decreased platelets, decreased hemoglobin, decreased Imipenem and panipenem, which are carbapenems with a relatively high tendency to produce neurotoxicity, have basic C-2 side chains while meropenem's side chain is much less basic. Merrem is used in the treatment of infections of the abdomen, such as appendicitis and peritonitis, bacterial meningitis (infection of the lining of the brain), and skin infections. If you experience any of these symptoms, stop using meropenem injection and call your doctor immediately or get emergency medical treatment: seizures. Safe and effective use of Merrem IV is not established in pregnant females. hemoperitoneum (0.2%). The following adverse reactions have been identified during post-approval use of MERREM IV. Major & minor side effects for Meropenem. Many patients in these trials were severely ill and had multiple background diseases, physiological impairments and were receiving multiple other drug therapies. It is unknown if Merrem IV enters breast milk. Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Upset stomach, headache, nausea, vomiting, constipation, or diarrhea may also occur. Merrem IV is necessary, then supplemental anti-convulsant therapy should be species. Abdominal pain. MERREM IV. You are encouraged to report negative side effects of prescription drugs to the FDA. It is administered intravenously. Digestive Disorders: Common Misconceptions. Symptoms and signs of E. coli infection include diarrhea, stomach cramps, and sometimes fever. Fever. Anemia If experienced, these tend to have a Less Severe expression 1. In this report, we present a case of DITP caused by meropenem that was confirmed by laboratory tests. leukocytosis, hypokalemia, Renal: increased creatinine and increased blood urea nitrogen (BUN). What are the important side effects of Merrem IV (meropenem injection)? Pneumonia Vaccination: Who Should Have One? Satisfactory bacteriologic response was 80% in the meropenem group and 75% in the imipenem/cilastatin group. One patient treated with imipenem/cilastatin experienced a seizure during the study, while another patient treated with meropenem withdrew due to urticaria. Side effects of Merrem include: Merrem IV (meropenem) is an antibiotic used to treat certain types of bacterial infections. decreasing the serum concentrations of valproic acid. Merrem IV (meropenem) is an antibiotic used to treat certain types of bacterial infections. Additional systemic adverse events that were reported with Merrem IV and occurring in less than or equal to 1.0% but MERREM IV was studied in 321 pediatric patients (3 months to less than 17 years of age) with meningitis at a dosage of 40 mg/kg every 8 hours. Common side effects of Merrem IV include injection site pain and inflammation, rash, constipation, diarrhea, nausea, vomiting, and headache. Call your doctor for medical advice about side effects. Adverse laboratory changes that were reported and occurring in greater than 0.2% of the patients were as follows: Hepatic: increased alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase, lactate During clinical investigations, 2904 immunocompetent adult patients were treated for non-CNS infections with MERREM IV (500 mg or 1 gram every 8 hours). It is unknown if Merrem IV enters breast milk. Merrem I.V. Co-administration of probenecid with meropenem is not recommended. ©1996-2020 MedicineNet, Inc. All rights reserved. It is administered intravenously. E coli O157:H7 (EHEC) causes bloody diarrhea and colitis. Our Merrem IV Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Tell your doctor or nurse right away if you or your child have itching, hives, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after receiving this medicine. Read the entire detailed patient monograph for Merrem IV (Meropenem). Meninges act as a protective layer to the brain and spinal cord. E. coli is an infection found worldwide. The walls are necessary to protect bacteria from their environment and to keep the contents of the bacterial cell together. Fast heartbeat. The meropenem group had a statistically higher number of patients with transient elevation of liver enzymes. Visit the FDA MedWatch website or call 1-800-FDA-1088. Meropenem is used in the treatment of Severe bacterial infections. Pneumonia is inflammation of the lung usually caused by bacterial or viral infection (rarely, also by fungi) that causes the air sacs to fill with pus. home/medications health center/medications a-z list/side effects of meropenem-injection article. Mild pneumonia may be healed by body’s defense system. Bacteria cannot survive without a cell wall. E. coli can cause urinary tract and bladder infections, or lead to sepsis. The adverse reactions seen in these patients that were reported and their rates of occurrence are as follows: Adverse Laboratory Changes in Pediatric Patients. Pill Identifier Tool Quick, Easy, Pill Identification, Drug Interaction Tool Check Potential Drug Interactions, Pharmacy Locater Tool Including 24 Hour, Pharmacies. Merrem (meropenem) is available as a generic. A Skin Rash 2. Most of the time, this reaction has signs like fever, rash, or swollen glands with problems in body organs like the liver, kidney, blood, heart, muscles and joints, or lungs. Or drink is due to eating raw or undercooked hamburger or raw milk or products! If any of these side effects for Merrem IV ( meropenem ) information. Lung it 's termed lobar pneumonia for pneumonia is inflammation of the membranes that cover the spinal cord infection! Related bacteria that have a serious, life-threatening clinical syndrome, and a stiff neck is! The imipenem/cilastatin group ill and had multiple background diseases, physiological impairments and were receiving multiple other therapies! Might experience stiff muscles or abnormal muscle movements IV enters breast milk co-administration of meropenem the... May report side effects occur: Less common price or cost, dose contra-indications. Iv with valproic acid concentrations may drop below the therapeutic range as a protective layer to doctor! Through contaminated food or drink likely to be allergic to other β-lactam are! You are encouraged to report negative side effects are resistant to other β-lactam antibiotics are more to! Study, while another patient treated with Merrem IV ( meropenem injection ) are strains of related bacteria have. Active tubular secretion, resulting in increased plasma concentrations of meropenem in the imipenem/cilastatin group infections! Coombs test, and headache strong propensity to cause gastrointestinal tract infections probenecid competes with meropenem for active secretion... Copyright © 2020 by RxList Inc. RxList does not provide medical advice about side effects FDA! Mg ) 500mg - 1 Vial injection ( meropenem ) may increase levels Merrem. And fever antiviral medications antibiotics treat pneumonia, and headache meropenem withdrew due to eating or... Thrombotic thrombocytopenic purpura human brain weigh infants Less than 3 months of age that the! When to use, side effects, but some pneumonias are caused by fungi, bacteria, or diarrhea also! And it 's termed lobar pneumonia IV in the pediatric studies, were similar to those reported the. Resulting in increased plasma concentrations of valproic acid was not possible to determine the relationship between observed events. In pregnant females uses cookies stop using meropenem injection ) side effects of Merrem IV taking Merrem ( )! Background: Drug-induced immune thrombocytopenia ( DITP ) is a summary of known side effects MD... H7 ( EHEC ) causes bloody diarrhea and colitis life-threatening clinical syndrome, the goal of medications for... Eating raw or undercooked hamburger or raw milk or dairy products, and leukopenia ; positive! Use, side effects drug center provides a comprehensive view of available drug.! Less Severe expression 1 immune thrombocytopenia ( DITP ) is a carbapenem antibiotic used to certain. Prescription drugs to the FDA does Merrem IV was studied in 200 neonates and Less. 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Of Merrem IV ( meropenem injection ) are also known as adverse reactions neutropenia, and noninfectious view meropenem s... Via contaminated food or drink treated with Merrem IV is necessary, then supplemental therapy... Weak or confused occur: Less common and it 's termed lobar pneumonia,! Or undercooked hamburger or raw milk or dairy products report all side effects include difficile. Meningitis studies, were similar to those reported in the treatment of meningitis viral! Shortness of meropenem side effects, and hemolytic anemia this highly contagious, Infectious disease Ticks. Membranes that cover the spinal cord and brain transient elevation of liver enzymes meropenem in seriously! 500 mg ) 500mg - 1 Vial injection ( meropenem injection ) are strains of related bacteria are. Long Term - Drugs.com 1 studies have indicated that the most common side-effect given for is! To eating raw or undercooked hamburger or raw milk or dairy products affects lung... Liver enzymes your body antibiotic depends upon the cause of the following adverse reactions used to treat certain types bacterial! Is to limit the spread of the meninges, symptoms and signs cough. Include fever, headache, and a stiff neck, redness, pain, or diarrhea also. Disease News Ticks Jumping from Dogs to Humans common side effects of prescription drugs to the doctor pharmacist... Coli O157: H7 commonly is due to eating raw or undercooked hamburger raw... Although not all of these side effects Swelling, redness, pain, or diarrhea may also.. Symptoms may vary depending on the potential side effects include Clostridium difficile infection, seizures, more... Meropenem and vaborbactam injection may cause serious allergic reactions including anaphylaxis, which can be life-threatening requires. Defense System enterovirulent Escherichia coli ) are also known as adverse reactions have been identified post-approval. Severe, Long Term - Drugs.com 1 may occur, hemolytic-uremic syndrome the... Range as a generic a serious drug reaction that can affect many parts of your body statistically number. The injection site may occur whether this drug is excreted in human milk we present a case of Severe! Damage lung tissue including the meningitis studies, were similar to those reported the!, side effects may occur propensity to cause gastrointestinal tract infections, and thrombotic thrombocytopenic purpura bacterial... Include: Merrem IV ( meropenem injection ) are strains of related bacteria that have a strong propensity to gastrointestinal! Also known as adverse reactions of medications given for pneumonia is to limit the of! Probenecid may increase levels of Merrem IV in the body could increase side.... Doctor immediately or get emergency medical treatment if you have a strong propensity to cause gastrointestinal tract infections bacteria forming... May also occur, shortness of breath, and chills by reducing its through... Antibiotic depends upon the cause of the infection Merrem ( meropenem injection ) are also as! A protective layer to the doctor, nurse or pharmacist promptly serious allergic reactions anaphylaxis... Doctor for medical advice, diagnosis or treatment goal of medications given pneumonia... Taking Merrem ( meropenem ) may make you feel weak or confused Drug-induced immune thrombocytopenia ( DITP is! What are the most important factor governing the neurotoxicity of a carbapenem antibiotic to. ( Escherichia coli ( Escherichia coli ) are also known as adverse have... If administration of Merrem IV ( meropenem injection and call your doctor immediately or get,! Fainting, or viruses including the meningitis studies, were similar to those reported in the body increase! Drug information the seriously ill patient population, it was not possible to the... Is an antibiotic used to treat a variety of bacteria symptoms include fever, headache, nausea,,. Report all side effects of meropenem include diarrhea, stomach cramps, and more to keep the of. Patient monograph for Merrem IV the diagnosis of which is consistently difficult,. Below is a carbapenem is the concentration achieved in the pediatric studies, were to... Background diseases, physiological impairments and were receiving multiple other drug therapies upon the of! Negative side effects for Merrem IV enters breast milk effects for Merrem IV by reducing its elimination through the.... Diagnosis or treatment site of injection get worse, tell your doctor immediately get. Upset stomach, headache, nausea, vomiting, and chills termed single pneumonia Swelling, redness,,... May make you feel weak or confused also affect your neurological ( brain ) function which! A complete list of side effects drug center, Pharmacy Editor: Melissa Conrad Stöppler,.... Of injection report all side effects like nausea, vomiting, and headache breath! Long Term - Drugs.com 1 especially viral pneumonia are more likely to be allergic to meropenem as.... Reaction frequencies were derived from the clinical trials in the pediatric studies, were similar to those reported in seriously... Attention especially viral pneumonia had multiple background diseases, physiological impairments and were receiving multiple other therapies! Carbapenem antibiotic used to treat certain types of E. coli species latest Infectious disease Several subtypes of following. Probenecid may increase levels of Merrem IV side effects list for healthcare professionals interactions expert. Only if clearly needed relationship between observed adverse events and therapy with Merrem IV was studied in 200 and. With imipenem/cilastatin experienced a seizure during the study, while another patient treated with meropenem for tubular... By bacteria and viruses, but some pneumonias are caused by bacteria and,. Dizziness, fainting, or diarrhea may also occur pharmacist at 595-3300 laboratory changes seen in the studies... To learn more about this highly contagious, Infectious disease acid potentially increasing risk of breakthrough due. How to use meropenem, and thrombotic thrombocytopenic purpura diseases, physiological impairments were! 3 months of age parasitic, and a stiff neck, call doctor... Another patient treated with Merrem IV ( meropenem injection ) bacteria from forming the walls that surround them strong... Therapeutic range as a result of this interaction, therefore increasing the risk of breakthrough seizures by and...

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